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Current and Recent Research Grants

Research Grants jointly sponsored by the NNPDF and CCNNPDF
Fellowships jointly sponsored by the NNPDF and CCNNPDF
Clinical Research and Services funded by the NNPDF

 

Postdoctoral Research Fellowships

The CCNNPDF and the NNPDF are pleased to be able to jointly sponsor the following fellowships:

Dr. Andrew Munkacsi

Defining the molecular basis of HDAC inhibitors to treat murine, feline, and human models of NPC
Sponsored by Stephen L. Sturley, Ph.D., Columbia University Medical Center; New York, New York; USA
Dr. Munkacsi's fellowship began September 2011 - updates will be posted to this page when available

Dr. Nicholas Cianciola
Activation of an alternative cholesterol homeostatic mechanism in NPC
Sponsored by Cathleen Carlin, Ph.D., School of Medicine, Case Western Reserve University; Cleveland, Ohio; USA
Two years September 2010 - September 2012  $100,000 (funding extended a third year to September 2013)
Read the Lay Summary for Dr. Cianciola's project (Oct 2011)

Dr. Dorothea Maetzel
In Vitro modelling of Niemann-Pick type C Disease Using Patient-Specific Induced Pluripotent Stem Cells

Sponsored by Rudolf Jaenisch, M.D., Whitehead Institute for Biomedical Research; Cambridge, Massachusetts; USA
Two years September 2010 - September 2012   $100,000 (funding extended a third year to September 2013)
Read the Lay Summary for Dr. Maetzel's project (Oct 2011)

Dr. Fabrizio Vacca
Analysis of cholesterol export from purified endosomes in NPC cellular models
Sponsored by Professor Jean Gruenberg, University of Geneva, Switzerland.
Two years April 2010 – April 2012   $100,000

Read the Lay Summary for Dr. Vacca's project   (Oct 2011)

Dr. Ian Martin Williams
Neurobiology of Purkinje Cells in NPC1
Sponsored by Professor Fran Platt, University of Oxford, UK
Two years September 2009 – September 2011   $100,000

Read the Lay Summary for Dr. Williams' project  (Nov 2011)

The research funded by the NNPDF is made possible in great part due to the efforts of our NPD families and their extended support network via local community-sponsored events, and support from the CCNNPDF. The NNPDF is truly grateful for this support.

The Canadian Chapter of the National Niemann-Pick Disease Foundation (CCNNPDF) is a sister chapter to the National Niemann-Pick Disease Foundation (NNPDF) (U.S.) and receives administrative support from the NNPDF. Money raised through the CCNNPDF is invested in Niemann-Pick Disease research through the NNPDF's research program with guidance from the NNPDF's Scientific Advisory Board (SAB), Board of Directors, and Research Committee. This partnership helps eliminate redundancy and maximizes the impact of our research dollars. (Tammy Vaughan, chair of the CCNNPDF, serves as secretary of the NNPDF, and is on the NNPDF's Research Committee.)

[Nov 4, 2010 mem]
[updated Nov 28, 2011 mem]


Mouse Model Grant to Jackson Laboratory

The NNPDF is pleased be able to provide $2500 to help defray the costs of processing the mouse model related to Niemann-Pick Disease.  The mouse model was created by Dr. Richard Pagano of the Mayo Clinic College of Medicine and is being processed by the Jackson Laboratory Repository.  

The nonprofit Jackson Laboratory Repository in Bar Harbor, Maine, serves as a centralized NIH-funded facility for mouse models used by the international biomedical research community, in both academic and nonprofit institutions. 

[Jan 20, 2010 mem]


Edward H. Schuchman, Ph.D. (Mount Sinai School of Medicine). Construction & Characterization of New Mouse Models for Types A & B Niemann-Pick.   Click here to read a September 2008 progress summary.    Click here to read the May 2009 progress summary.

Frances M. Platt, Ph.D. (Dept. of Pharmacology, University of Oxford).  Targeting sphingosine storage as a new therapeutic approach for Niemann-Pick Type C.  Click here to read the October 2008 progress summary.   Click here to read the March 2009 progress summary.      Click here to read the October 2009 progress summary.

Seymour Packman, MD, Director, UCSF-Stanford Lysosomal Disease Center
Underwritten by a grant from Genzyme Corporation

(To see a listing of Fellowships funded by the NNPDF, click here.)

(To see a listing of Research Grants funded by the NNPDF, click here.)

(To see a listing of Clinical Research and Services funded by the NNPDF, click here.)

[June 22, 2009 mem]

“The National Niemann-Pick Disease Foundation (NNPDF) does not engage in the practice of medicine. It is not a medical authority nor does it claim to have medical knowledge. This site is an educational service of the National Niemann-Pick Disease Foundation and is not meant to provide diagnostic or treatment advice. Information contained or suggested on this Web site does not constitute medical advice. For all information related to care, medication or treatment, the NNPDF recommends consulting a physician to determine if information presented is applicable. Please review these additional cautions about medical information provided on the Internet.”